![]() ![]() With the advent of next-generation sequencing and other technologies, a highly diverse and heterogeneous molecular landscape underlying TNBC has been revealed, and multiple molecular subclassifications have been established. 2, 3 Distant failure is a seminal event in the natural history of TNBC, with a 5-year overall survival (OS) rate of approximately 25% and median survival of 24 months in women with metastatic disease. 1 This is driven primarily by an increased propensity for distant failure compared with other subtypes of breast cancer, particularly within the first 5 years of diagnosis. As a group, patients with this subtype of breast cancer have a relatively worse prognosis than women with non-TNBC. Triple-negative breast cancer (TNBC) is an often-used surrogate for the basal subtype of breast cancer defined by the lack of estrogen receptor (ER) and progesterone receptor (PR) expression and HER2 gene amplification. In patients with residual disease after NAC, pathologic lymph node positivity and lymphovascular space invasion predicted worse FFDM. Conclusions: Lack of pCR after NAC resulted in worse overall survival and FFDM, despite trimodality therapy. Patients with a greater number of factors had worse FFDM 5-year FFDM was 76.5% for patients with no factors (n=38) versus 54.9% and 27.5% for patients with 1 (n=44) and 2 factors (n=26), respectively ( P<.001). Factors independently predicting FFDM in patients without pCR were pathologic nodal positivity (hazard ratio, 3.08 95% CI, 1.54–6.14 P=.001) and lymphovascular space invasion (hazard ratio, 1.91 95% CI, 1.07–3.43 P=.030). Five-year FFDM was 98% and 55% in patients with and without pCR, respectively ( P<.001). After NAC, 108 had residual disease (pCR, 29%). Results: We identified 153 patients with median follow-up of 4.0 years (range, 0.5–14.0 years). In patients without pCR, univariate and multivariable Cox analyses were used to determine factors predictive of distant metastasis. Freedom from distant metastasis (FFDM) was compared between patients with and without pCR using the Kaplan-Meier method. ![]() Methods: Women with TNBC treated with NAC, surgery, and radiation therapy in 2000 through 2013 were reviewed. This study investigated factors predictive of distant metastasis in TNBC without pCR after NAC. However, most patients do not experience pCR, and other risk factors for distant metastasis after NAC are poorly characterized. The main focus of the guidance is to discuss the use of pathological complete response (pCR) in high-risk early-stage breast cancer as a potential endpoint to support approval under the accelerated approval regulations (21 CFR part 314, subpart H, for new drug applications and 21 CFR part 601, subpart E, for biologics license applications).Background: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC) predicts decreased distant metastasis. This guidance is intended to assist sponsors in designing trials to support marketing approval of drugs and biological products for the treatment of high-risk early-stage breast cancer in the neoadjuvant (preoperative) setting. ![]()
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![]() ![]() The video production company you’re working with bring their crew, equipment, talent (actors) and all necessary props out to the location and capture all the footage necessary. Production is the actual filming of the video. The action of making or manufacturing from components or raw materials or the process of being so manufactured. But unfortunately, spending the appropriate amount of time in pre-production to nail down the video’s concept is often an overlooked step in the production process. Having a strong concept is an essential component of a video. It’s where we get all of the ducks in a row so the rest of the production process is as smooth as gravy. Pre-production is the work done on a product, especially a film or broadcast program before full-scale production begins.Įlements of video production such as the script, casting, location scouting, equipment and crew, and the shot list all happen during pre-production. The production process, in a nutshell, is pre-production → production → post production. And some of our clients have asked us to elaborate on the subject matter, so here it is. To us, pre-production is a term we use in our vocabulary daily, so it’s easy to use the term with clients without realizing they may not know what the terms pre-production, production, and post-production actually mean or what they entail.īut you know us, ask and you shall receive. Whether on location or in the head office, our expert team will deliver everything you need.What does that even mean? Working in a video production company here in Orlando, it is easy to see why we often use terminology specific to video production and forget that most people do not know what all encompasses any given term. You get a fixer on location as well as on-call support from our head office in London. Let us guide your project from research and pre-production through to post-production. 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I am trying to install JRE on a communal computer so that I can build and run a split HSQL 2.x database. ![]() ![]() Spin-offs and all can feature some other protagonist but the main series has always been defined by Kratos. So, if there’s going to be a proper God of War title, Kratos has to be the one to lead it. It has to be Kratos.Īs fun it was, playing as Atreus at various moments in the game, Kratos was, is, and will remain the heart and soul of the franchise. Another question is who will lead the game, which brings us back to what we were talking about above. 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The below open source feeds look like a great starting point providing STIX/TAXII support.In your RocketCyber console, now navigate to Integrations / Threat Intel (Make sure you are logged in context at the root MSP level for this threat feed to be applied across your fleet of customers.).Navigate to API Integration and copy Your OTX Key.Register for a free Alienvault API Key at.This threat intelligence feed contains more than 19 million threat indicators and is consumed with your RocketCyber SOC subscription, then put into action across your endpoints under management, delivering an extra layer to your security stack's continuous monitoring strategy. If you need help or have a subreddit suggestion, send a note to /u/JonathanP_QRadar.This article explains how to set up and use the Alienvault OTX threat intelligence feed with the RocketCyber SOC platform.Īlienvault's Open Threat Exchange® (OTX™) is one of the world’s largest open threat intelligence communities, with 1,000's of threat researchers and security professionals across the globe.Now I have the problem that no 'items' are retrieved from the TAXII server. Be kind to one another, everyone is here to help out. I am currently trying to integrate the TAXII Feed provided by Alienvault OTX into QRadar.There is no such thing as a bad question.This subreddit is not a substitution for direct QRadar Support assistance / cases.Do not post logs from appliances, pastebin links, or use any identifiable information in this subreddit.For previous QRadar Open Mic sessions, see Open Mic List Alienvaults Open Threat Exchange® (OTX) is one of the world’s largest open threat intelligence communities, with 1,000s of threat researchers and security professionals across the globe. ![]() For QRadar events, see the IBM Community Event Calendar.Choose the workspace to which you want to import threat indicators from the TAXII server. Alien Vault OTX feed URL Weight 1 Interval 43200 POST arguments taxiiusername'' taxiipassword'poo' Maximum age -30d I am really frustrated and would really appreciate anyones help. Reason for failure: Taxii Error: HTTP Error: status code 400 bad request). If you ask a question, always include your QRadar version with your question. To import threat indicators into Microsoft Sentinel from a TAXII server, follow these steps: From the Azure portal, navigate to the Microsoft Sentinel service. All Discussions Previous Discussion Next Discussion 7 Replies PawelGiza. ![]() Has anyone had success with this or other TAXII feeds Thanks 4,831 Views. This page is moderated by QRadar Support. I am trying to integrate AlienVaults OTX TAXII feed as a data connector, and I keep getting 'unexpected' errors. A place for administrators to talk about QRadar, share information, ask questions, and learn. ![]() ![]() Trae is a heck of a player we are excited to have him. “Luka is a heck of a player we were happy with him. “Two of our goals in the next few years is to accumulate as many assets as we can and to get as much talent as we can,” Hawks GM Travis Schlenk told the Atlanta-Journal Constitution before the season started. The Mavs took Luka Doncic with the third choice. 3 pick to the Dallas Mavericks in exchange for the No. According to many reports, Trae was the guy that Atlanta wanted from jump-so, when the Draft came, the franchise had no problem with trading its No. Kinda hard to do your thing when you’re double- and triple-teamed every possession, right?īut even with the stats tapering off toward the end of the Sooners’ season, the Hawks never wavered in their feelings for Young. ![]() He had offensive outbursts of 43 and 39 before New Year’s Eve, but as defenders wised up, those numbers came down. Introduced to the masses last year at Oklahoma during a freshman campaign in which he showed the moves of Steph and the range of Sprint, Young literally did things previously unseen in college-like being the first player to lead the NCAA in points and assists in the same season. You never know what you’re going to get, but I’m excited.”Īt this point Young’s backstory is old news. You never know what to expect in any sport when you draft. ![]() “ amazing,” says Schafer, of the franchise-building point guard whose face is already plastered on billboards across the city and, of course, on the cover of tonight’s program. This man leads a staff of hundreds for every State Farm Arena event, but even he knows that there’s another person in the building with much more on his plate these days. Follow the aroma of grilled chicken and freshly baked brownies down to the sleek, floor-level Chef’s Club and you’ll run into Joe Schafer, the executive chef for the venue’s entire culinary program. The whole organization knows what Trae means. At this time, you’ve been through so much. “There’s a little bit of anxiousness, nervousness, a little bit of everything. “I’m excited,” Young says of his rookie season during the Hawks’ media day Facebook forum with fans. They only hope that the energy the fans show in the stands after a dope crossover doesn’t completely dissipate after a dumb turnover. But he’s 20 and hasn’t met a 30-footer he doesn’t like, so there are destined to be a few frustrating moments as well. ![]() In this rebuilding season-literally and figuratively-the super-gifted kid out of Norman, OK, is going to be responsible for some fun times around the gym. The team brought in a bright new face, too, and it belongs to Trae Young. There are so many changes to the former Philips Arena that, when an usher hands out souvenir programs, everyone excitedly grabs one for the map inside. This rehab called for a full gutting-we’re talking new concourse layouts, new TopGolf suites, a new jumbotron roughly the size of Cobb County, new everything. Inside, things are even crazier with fans and media ogling over a facility that’s unveiling a $200 million makeover, the second-biggest renovation in NBA history. It’s the Atlanta Hawks’ home opener and radio stations and marching bands are blasting music outside. There’s a certified buzz around State Farm Arena. ![]() |